Significant correlation for genetic risk score with FEV1, FVC per BMI-increasing allele
MONDAY, July 10, 2017 (HealthDay News) — There is a causal relationship between increasing body mass index (BMI) and asthma and decreased lung function, according to a study published online July 4 in Allergy.
Tea Skaaby, Ph.D., from the Center for Health in Denmark, and colleagues examined the causal effect of BMI on asthma, hay fever, and allergic sensitization. Data were included for 490,497 and 162,124 participants in observational and genetic analyses, respectively. Using 26 BMI-associated single nucleotide polymorphisms, the authors created a genetic risk score (GRS).
The researchers found that per BMI-increasing allele there was a significantly correlation for GRS with asthma (odds ratio, 1.009; 95 percent confidence interval, 1.004 to 1.013), but not with hay fever (odds ratio, 0.998; 95 percent confidence interval, 0.994 to 1.002) or with allergic sensitization (odds ratio, 0.999; 95 percent confidence interval, 0.986 to 1.012). There was a significant correlation for GRS with decrease in forced expiratory volume in one second (β = −0.0012; 95 percent confidence interval, −0.0019 to −0.0006) and in forced vital capacity (β = −0.0022; 95 percent confidence interval, −0.0031 to −0.0014) per BMI-increasing allele.
“The results support the conclusion that increasing BMI is causally related to higher prevalence of asthma and decreased lung function, but not with hay fever or biomarkers of allergy,” the authors write.
One institution was partially funded by a donation from the Novo Nordisk Foundation.
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