Efficacy of atropine is independent of dose, while adverse effects are dose dependent
THURSDAY, May 18, 2017 (HealthDay News) — Adverse effects are less frequent at lower doses of atropine, and higher doses are not more effective in reducing progression of myopia in children, according to a meta-analysis published online May 11 in JAMA Ophthalmology.
Qianwen Gong, M.D., from Sichuan University in Chengdu, China, and colleagues examined the efficacy versus the adverse effects of atropine in treatment of myopia in children in randomized clinical trials and cohort studies. Data were included for 19 unique studies with 3,137 unique children, aged younger than 18 years.
The researchers found that the weighted mean differences between the atropine and control groups in myopia progression were 0.50, 0.57, and 0.62 diopters per year for low-, moderate-, and high-dose atropine, respectively (P < 0.001), which translated to a high effect size (Cohen d of 0.97, 1.76, and 1.94, respectively). With respect to myopia progression, all doses of atropine were equally beneficial (P = 0.15). There were more adverse effects with high-dose atropine (incidence of photophobia, 43.1, 17.8, and 6.3 percent, respectively, for high-, moderate-, and low-dose atropine; P = 0.03). There were no differences in the incidence of adverse effects between Asian and white patients (P = 0.37 for photophobia).
“This meta-analysis suggests that the efficacy of atropine is dose independent within this range, whereas the adverse effects are dose dependent,” the authors write.
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