Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for December 2017. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Intensive Lifestyle Intervention Linked to Cerebral Blood Flow
WEDNESDAY, Dec. 27, 2017 (HealthDay News) — A long-term intensive lifestyle intervention (ILI) in overweight and obese adults with type 2 diabetes mellitus is associated with greater cerebral blood flow (CBF), according to a study published recently in the Journal of the American Geriatrics Society.
Risk of ESRD in T1DM Patients Has Fallen Markedly in Finland
WEDNESDAY, Dec. 27, 2017 (HealthDay News) — The cumulative risk of end-stage renal disease (ESRD) among patients with type 1 diabetes has declined over time in Finland, according to a study published online Dec. 20 in Diabetes Care.
Calcium, Vitamin D Don’t Seem to Reduce Fracture Risk in Seniors
WEDNESDAY, Dec. 27, 2017 (HealthDay News) — For community-dwelling older adults, supplementation with calcium, vitamin D, or both does not reduce the incidence of fractures, according to a review published in the Dec. 26 issue of the Journal of the American Medical Association.
Text Message Interventions May Help With Weight Management
TUESDAY, Dec. 26, 2017 (HealthDay News) — Extended-contact, text-message-delivered interventions appear to be effective for weight management, according to a review published online Dec. 15 in Obesity Reviews.
Plasma Volume Changes May Mediate Effects of Empagliflozin
TUESDAY, Dec. 26, 2017 (HealthDay News) — The reduction in risk of cardiovascular (CV) death with empagliflozin is most mediated by changes in hematocrit and hemoglobin, according to research published online Dec. 4 in Diabetes Care.
Bone Fragility Variants Linked to Concordant Pediatric Skeleton
THURSDAY, Dec. 21, 2017 (HealthDay News) — Established bone fragility variants are associated with a concordant phenotypic model of the pediatric skeleton but not with discordant phenotypic models, according to a study published online Dec. 14 in the Journal of Bone and Mineral Research.
CDC: 2015 to 2016 Saw Drop in Life Expectancy in United States
THURSDAY, Dec. 21, 2017 (HealthDay News) — From 2015 to 2016, life expectancy decreased by one-tenth of a year, and there was an increase in the rate of age-adjusted drug overdose deaths, according to two December data briefs published by the U.S. Centers for Disease Control and Prevention’s National Center for Health Statistics.
Abstract/Full Text – Kochanek
Abstract/Full Text – Hedegaard
Pioglitazone Associated With Lower Blood Leptin in Diabetes
THURSDAY, Dec. 21, 2017 (HealthDay News) — Compared to placebo, pioglitazone is associated with significantly lower blood leptin levels in patients with type 2 diabetes, according to a meta-analysis published online Dec. 1 in the Journal of Diabetes Investigation.
Higher TSH Levels Seen in Women With Unexplained Infertility
WEDNESDAY, Dec. 20, 2017 (HealthDay News) — Women with unexplained infertility (UI) have higher thyroid-stimulating hormone (TSH) levels than women with a normal fertility evaluation, according to a study published online Dec. 19 in the Journal of Clinical Endocrinology & Metabolism.
DPP-4 Inhibitor Has Dissociated Effects on β-Cell Function
WEDNESDAY, Dec. 20, 2017 (HealthDay News) — For healthy adults and individuals with well-controlled type 2 diabetes (T2D), a single dose of the dipeptidyl peptidase-4 inhibitor sitagliptin is associated with increased standardized insulin secretion, with no impact on β-cell glucose sensitivity, according to a study published online Dec. 11 in Diabetes, Obesity and Metabolism.
RA Exposure In Utero Tied to Increased Disease Risk
TUESDAY, Dec. 19, 2017 (HealthDay News) — Children born to mothers with rheumatoid arthritis may have an increased risk of rheumatoid arthritis, thyroid disease, and epilepsy, according to a study published online Dec. 11 in Arthritis Care & Research.
Pre-Op Liraglutide Cuts Post-Op Plasma Glucose in T2DM
TUESDAY, Dec. 19, 2017 (HealthDay News) — For patients with type 2 diabetes mellitus undergoing non-cardiac surgery, premedication with liraglutide is associated with reduced median plasma glucose one hour postoperatively, according to a study published online Dec. 12 in Anaesthesia.
Intensive BP Goals Reduce Risk of Cardiovascular Events
TUESDAY, Dec. 19, 2017 (HealthDay News) — Intensive blood pressure lowering may similarly decrease cardiovascular events in both patients with and patients without type 2 diabetes mellitus, according to a study published online Dec. 6 in Diabetes Care.
Male U.S. Doctors Receive Higher Values of Industry Payments
MONDAY, Dec. 18, 2017 (HealthDay News) — Male physicians in the United States received higher values of general payments from industry than females in 2015, according to a research letter published online Dec. 18 in JAMA Internal Medicine.
Emergency-Only Hemodialysis Linked to Worse Outcomes
MONDAY, Dec. 18, 2017 (HealthDay News) — Emergency-only hemodialysis treatment is associated with increased mortality compared with standard hemodialysis for undocumented immigrants with end-stage renal disease, according to a study published online Dec. 18 in JAMA Internal Medicine.
Abstract /Full Text
Microbiome Intervention With Niacin Aids Insulin Sensitivity
MONDAY, Dec. 18, 2017 (HealthDay News) — A targeted microbiome intervention, accomplished through microencapsulated delayed-release niacin, beneficially affects insulin sensitivity in humans, according to a study published online Dec. 6 in Diabetes Care.
Yogurt, But Not Milk, May Lower Hip Fracture Risk
MONDAY, Dec. 18, 2017 (HealthDay News) — High intake of fermented milk products, like yogurt, in combination with a high intake of fruits and vegetables, is associated with lower hip fracture rates in women, according to a study published online Nov. 27 in the Journal of Bone and Mineral Research.
Year One Results Out for Value-Based Payment Modifier Program
MONDAY, Dec. 18, 2017 (HealthDay News) — Almost 30 percent of eligible practices failed to register and report data in the first year of the Physician Value-Based Payment Modifier program, according to a report published in the December issue of Health Affairs.
Payment for Laboratory Tests Set to Reduce Starting Jan. 1, 2018
MONDAY, Dec. 18, 2017 (HealthDay News) — The Centers for Medicare & Medicaid Services (CMS) has released the Clinical Laboratory Fee Schedule, which is set to reduce payments for testing services conducted in physician office-based laboratories, according to a report published by the American Medical Association (AMA).
Doctors Must Report on at Least 1 Patient, 1 Measure for MACRA
FRIDAY, Dec. 15, 2017 (HealthDay News) — In order to meet the 2017 Medicare and CHIP Reauthorization Act (MACRA) participation reporting deadline and avoid a Medicare payment penalty in 2019, physicians must report on at least one patient and one measure by Dec. 31, and submit to Medicare no later than Feb. 28, 2018, according to a report from the American Medical Association (AMA).
Recent Decrease in Excess Risk of All-Cause Mortality in ESRD
FRIDAY, Dec. 15, 2017 (HealthDay News) — Among individuals with end-stage renal disease (ESRD), there was a decrease in the excess risk of all-cause mortality from 1995 to 2013, according to a study published online Dec. 14 in the Clinical Journal of the American Society of Nephrology.
Pharmacist Participation in Medical Homes Aids Outcomes
FRIDAY, Dec. 15, 2017 (HealthDay News) — A program that integrates clinical pharmacists into established primary care medical home practices helps patients achieve better disease management for high blood pressure (HBP) and diabetes mellitus (DM), compared to usual care, according to a study published recently in the Journal of International Medical Research.
Expanded TIMI Risk Score Deemed Practical in Diabetes
FRIDAY, Dec. 15, 2017 (HealthDay News) — The TIMI (Thrombolysis in Myocardial Infarction) Risk Score for Secondary Prevention (TRS 2°P) is an accurate predictor of atherothrombotic disease among patients with type 2 diabetes, according to a study published online Dec. 1 in Diabetes Care.
Prevalence of Diabetes Tops 20 Percent Among U.S. Veterans
THURSDAY, Dec. 14, 2017 (HealthDay News) — The overall prevalence of diabetes among U.S. veterans was 20.5 percent in 2013 to 2014, according to a study published online Dec. 14 in the U.S. Centers for Disease Control and Prevention’s Preventing Chronic Disease.
Making Insurers Participate in Marketplace Could Cut Volatility
THURSDAY, Dec. 14, 2017 (HealthDay News) — Requiring insurers that participate in Medicare or Medicaid to also participate in Marketplaces in the same geographic area could improve access to insurance, according to a study published in the December issue of Health Affairs.
Stricter Short-Term Glycemic Control May Increase Remission
THURSDAY, Dec. 14, 2017 (HealthDay News) — Stricter glycemic control during short-term intensive insulin therapy for newly diagnosed type 2 diabetes patients is associated with a higher likelihood of remission at one year, according to a study published online Nov. 30 in the Journal of Diabetes Investigation.
Telemedicine Facilitates Diabetes Foot Ulcer Care
THURSDAY, Dec. 14, 2017 (HealthDay News) — Telemedicine follow-up enables more comprehensive diabetes foot ulcer care, according to a study published online Nov. 29 in the Journal of Clinical Nursing.
Measuring Quality of Life Important With Diabetes Tx
WEDNESDAY, Dec. 13, 2017 (HealthDay News) — Patients with diabetes report worse quality of life (QoL) with more intensified treatment, according to a study published in online Nov. 28 in Diabetes Care.
Findings Support Individualized Glycemic Control in T2DM
TUESDAY, Dec. 12, 2017 (HealthDay News) — An individualized approach to glycemic control in type 2 diabetes is likely to reduce costs and improve quality of life, according to a study published online Dec. 12 in the Annals of Internal Medicine.
Artificial Intelligence Promising for CA, Retinopathy Diagnoses
TUESDAY, Dec. 12, 2017 (HealthDay News) — A deep learning algorithm can detect metastases in sections of lymph nodes from women with breast cancer; and a deep learning system (DLS) has high sensitivity and specificity for identifying diabetic retinopathy, according to two studies published online Dec. 12 in the Journal of the American Medical Association.
Abstract/Full Text – Benjordi (subscription or payment may be required)
Abstract/Full Text – Ting (subscription or payment may be required)
Editorial (subscription or payment may be required)
CABG May Be Best Method to Revascularize in Diabetes
TUESDAY, Dec. 12, 2017 (HealthDay News) — In patients with diabetes and multivessel coronary artery disease (MV-CAD), coronary artery bypass grafting (CABG) may be the preferred method of revascularization, with lower rates of major adverse cardiac or cerebrovascular events (MACCE), according to a study published in the Dec. 19 issue of the Journal of the American College of Cardiology.
FDA Approves Admelog for Diabetes
MONDAY, Dec. 11, 2017 (HealthDay News) — Admelog (insulin lispro), a short-acting form of insulin, has been approved by the U.S. Food and Drug Administration to treat patients aged 3 years and older with either type of diabetes.
Stair-Step Clomiphene Reduces Time to Ovulation in PCOS
MONDAY, Dec. 11, 2017 (HealthDay News) — The stair-step clomiphene protocol is associated with decreased time to ovulation for women with polycystic ovary syndrome (PCOS), according to a study published online Dec. 4 in Obstetrics & Gynecology.
β-Cell Sensitivity to Glucose Impaired After Gastric Bypass
MONDAY, Dec. 11, 2017 (HealthDay News) — Individuals with prior Roux-en-Y gastric bypass (GB) have blunted β-cell sensitivity to changes in glycemia, according to a study published online Nov. 20 in Diabetes, Obesity and Metabolism.
Deceleration in Health Care Spending Growth in 2016
MONDAY, Dec. 11, 2017 (HealthDay News) — Health care spending growth slowed in 2016 following faster growth in 2014 and 2015, according to research published online Dec. 6 in Health Affairs.
Bariatric Surgery Alters Liver Fatty Acid Metabolism
FRIDAY, Dec. 8, 2017 (HealthDay News) — Bariatric surgery seems to change fatty acid metabolism in the liver, according to a study published online Nov. 20 in Diabetes Care.
Moving More May Match Focused Exercise in Prediabetes
THURSDAY, Dec. 7, 2017 (HealthDay News) — The accumulation of total physical activity (PA) over the day may be as important as achieving the intensity of moderate-to-vigorous PA (MVPA) for improved cardiometabolic health of adults with prediabetes, according to a study published online Nov. 20 in Diabetes Care.
Metabolic Risk Factors Linked to Severe Liver Disease
THURSDAY, Dec. 7, 2017 (HealthDay News) — Metabolic risk factors are associated with severe liver disease, according to a study published online Nov. 22 in Hepatology.
Different Weight Loss Patterns Observed Following Bariatric Sx
WEDNESDAY, Dec. 6, 2017 (HealthDay News) — Different weight loss patterns are observed following Roux-en-Y gastric bypass (RYGB) and laparoscopic adjustable gastric banding (LAGB), with much of the weight loss maintained over time, according to a study published online Dec. 6 in JAMA Surgery.
FDA Approves Ozempic for Type 2 Diabetes
WEDNESDAY, Dec. 6, 2017 (HealthDay News) — A new once-weekly diabetes medication that lowers blood glucose and also helps patients lose weight has been approved by the U.S. Food and Drug Administration.
Program Aids Quality of Life for Older Adults With T2DM
WEDNESDAY, Dec. 6, 2017 (HealthDay News) — A community-based program improves quality of life and self-management in older adults with type 2 diabetes mellitus (T2DM) and comorbidities, according to a study published online Nov. 27 in the Journal of the American Geriatrics Society.
Thyroidectomy-Specific Quality Improvement Measures ID’d
WEDNESDAY, Dec. 6, 2017 (HealthDay News) — For patients undergoing thyroidectomy, hypocalcemia and recurrent laryngeal nerve (RLN) injury may be useful quality improvement measures, according to a study published online Nov. 29 in JAMA Surgery.
Remission of Type 2 Diabetes Feasible for Primary Care
TUESDAY, Dec. 5, 2017 (HealthDay News) — Intensive weight management implemented in primary care practices can result in remission of type 2 diabetes for almost half of patients, according to a study published online Dec. 5 in The Lancet.
Link Between Diabetes, Antibiotic Use Called Into Question
TUESDAY, Dec. 5, 2017 (HealthDay News) — Previous findings that systemic use of antibiotics increases the risk of diabetes may actually be explained by clinical and lifestyle factors, according to a study published online Nov. 20 in Diabetes, Obesity and Metabolism.
CVS-Aetna Merger Has Implications for Doctors’ Offices
TUESDAY, Dec. 5, 2017 (HealthDay News) — CVS Health’s planned purchase of insurance giant Aetna, a $69 billion deal, was announced Sunday.
More Information – NYT
More Information – HealthDay
Specialty Care Tied to Reduced Mortality in New-Onset A-Fib
MONDAY, Dec. 4, 2017 (HealthDay News) — Cardiologist care is associated with a lower rate of death in patients with new-onset atrial fibrillation (AF), according to a study published in the December issue of the Canadian Journal of Cardiology.
Adherence to T2DM Treatment Varies Across Medication Classes
MONDAY, Dec. 4, 2017 (HealthDay News) — There is considerable variation in adherence across medication classes for the treatment of type 2 diabetes (T2D), according to a review published online Nov. 14 in Diabetes, Obesity and Metabolism.
Almonds With/Without Chocolate May Improve Lipid Profiles
FRIDAY, Dec. 1, 2017 (HealthDay News) — Eating raw almonds, dark chocolate, and cocoa can significantly improve lipid profiles of overweight and obese people, according to a small study published online Nov. 29 in the Journal of the American Heart Association.
Fat Intake Influences HbA1c-Lowering Effect in DPP4i Therapy
FRIDAY, Dec. 1, 2017 (HealthDay News) — For individuals with type 2 diabetes (T2D), fat intake may contribute to the deterioration of the hemoglobin A1c (HbA1c)-lowering effects in dipeptidyl peptidase-4 inhibitor (DPP4i) monotherapy, according to a study published online Nov. 24 in the Journal of Diabetes Investigation.
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