Excess risk highest in those with celiac disease for 10 years or more
WEDNESDAY, Dec. 30, 2015 (HealthDay News) — Celiac disease (CD) is a risk factor for development of autoimmune thyroid disease (ATD) in patients with type 1 diabetes (T1D), according to a study published online Dec. 17 in Diabetes Care.
Matthew Kurien, M.D., from the Royal Hallamshire Hospital in Sheffield, U.K., and colleagues examined the risk of ATD for individuals with both T1D and CD in a population-based cohort study. Data were included for 947 individuals with T1D and small intestinal biopsy-verified CD. These patients were matched with 4,584 controls with T1D but without CD.
The researchers found that CD was a risk factor for later ATD in T1D. Ninety patients with T1D and CD developed ATD during follow-up (expected, 54). This corresponded with a hazard ratio [HR] of 1.67 after adjustment for sex, age, and calendar period (95 percent confidence interval [CI], 1.32 to 2.11; P < 0.001). Those who had CD for 10 years or more had the highest excess risk (HR, 2.22; 95 percent CI, 1.49 to 3.23). Both males and females had risk increases. CD was associated with increased risk for hypothyreosis (HR, 1.66; 95 percent CI, 1.30 to 2.12) and hyperthyreosis (HR, 1.72; 95 percent CI, 0.95 to 3.11).
“Among patients with T1D, CD is a risk factor for the later development of ATD,” the authors write.
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