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Oral estradiol therapy is associated with less progression of subclinical atherosclerosis in postmenopausal women when therapy is initiated early in menopause

Early Menopause Estradiol Tx Cuts Atherosclerosis Advance

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Positive effect seen only on carotid-artery intima-media thickness
Baricitinib

Baricitinib Superior to Placebo in Refractory Rheumatoid Arthritis

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Findings based on patients with previous inadequate response to biologics
The American College of Cardiology and the American Heart Association Task Force on Clinical Practice Guidelines has updated the recommendations regarding duration of dual antiplatelet therapy for patients with coronary artery disease. The updated practice guideline was published online March 29 in the Journal of the American College of Cardiology.

Guidelines Updated on Duration of Dual Antiplatelet Tx in CAD

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Longer-duration tx represents trade-off between decreased risk of cardiac events, increased bleeding
For patients with type 2 diabetes newly treated with antidiabetic drugs

Pioglitazone Linked to Increased Risk of Bladder Cancer

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Duration- and dose-response associations for pioglitazone; no correlation for rosiglitazone
Specific cannabis dependence risk alleles have been identified

Genetic Factors Associated With Cannabis Dependence Identified

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Genome-wide association ID'd three independent regions with single nucleotide polymorphisms
Women receiving trivalent influenza vaccination are less likely to experience a stillbirth

Stillbirth Less Likely for Women Receiving Trivalent Flu Vaccine

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Largest relative reduction in stillbirths seen for births occurring just after influenza season
For patients with rheumatoid arthritis and a first non-tumor necrosis factor inhibitor failure

Tocilizumab Treats Rheumatoid Arthritis After Non-TNFi Failure

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Better efficacy for tocilizumab versus abatacept and rituximab in patients with first non-TNFi failure
Longer-term antibiotic treatment does not improve health-related quality of life compared with shorter-term treatment among patients with persistent symptoms attributed to Lyme disease

No Benefit for Longer-Term Antibiotic Tx in Lyme Disease

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Longer-term antibiotic tx doesn't have additional beneficial effect on health-related quality of life
Extended-release naltrexone is associated with a lower rate of opioid relapse than usual treatment among criminal justice offenders

Naltrexone ER Injection Cuts Opioid Relapse Rate in Inmates

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Lower rate of relapse compared with usual treatment in trial involving criminal justice offenders
Defitelio (defibrotide sodium) has been approved by the U.S. Food and Drug Administration to treat a rare

FDA Approves First Tx for Disease Linked to Stem Cell Transplant

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Hepatic veno-occlusive disease is rare, but fatal