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The synthetic prostaglandin E1 analogue misoprostol has known severe side effects and should be considered in cases of postpartum hyperthermia

Misoprostol Should Be Considered in Postpartum Hyperthermia

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Report of 21-year-old with severe hyperthermia, rigors, tachycardia, transient encephalopathy
The endothelin-1 blocker macitentan does not reduce the number of new digital ulcers over 16 weeks among patients with systemic sclerosis and active ischemic digital ulcers

Macitentan Doesn’t Reduce Number of New Digital Ulcers

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Findings over 16 weeks among patients with systemic sclerosis and active ischemic digital ulcers
Esomeprazole accelerates aging of blood vessel cells in lab tests

PPI Exposure Accelerates Aging in Lab Endothelial Cells

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Findings could help explain recent reports linking long-term use to adverse effect on cardiovascular health
Low doses of ketamine may quickly reduce suicidal thoughts in patients with treatment-resistant depression

Ketamine May Ease Suicidal Thoughts in Major Depression

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Small study found that the drug worked quickly in patients with treatment-resistant depression
For patients with lipodystrophy

Metreleptin Ups Resting-State Connectivity in Lipodystrophy

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Significant increases in hypothalamus; insula, superior temporal gyrus; medial prefrontal cortex
A new study suggests that excessive amounts of folate and vitamin B12 in a mother's body might increase an infant's risk of developing an autism spectrum disorder. The study findings are scheduled for presentation at the International Meeting for Autism Research

Too Much Folate in Pregnancy Tied to Raised Autism Risk

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Mothers with very high blood levels of folate at delivery twice as likely to have a child with autism
For patients with acute ischemic stroke

Low-Dose Alteplase Not Noninferior for Ischemic Stroke

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For primary outcome of death and disability at 90 days, low dose not noninferior to standard dose
Ticagrelor is not superior to aspirin for patients with acute ischemic stroke or transient ischemic attack

Ticagrelor Doesn’t Beat Aspirin in Ischemic Stroke, TIA

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Ticagrelor not superior to aspirin for reducing composite of stroke, myocardial infarction, death
The number of fatal motor vehicle crashes involving marijuana more than doubled after Washington state legalized the sale of the drug

Marijuana-Linked Fatal MVAs Up in WA State After Legalization

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Experts say Washington state's experience could be a lesson for rest of country
The interim diagnostic testing guidance for Zika virus in public health laboratories has been updated

CDC Updates Zika Testing Guidance for Urine Samples

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CDC recs for Zika virus testing of serum and other clinical specimens remain unchanged at this time