Obesity at Pediatric Cancer Diagnosis Linked to Inferior Survival
Inferior event-free and overall survival seen for patients with obesity, especially children with ALL and CNS tumors
MEK Inhibition Beneficial for Children With Subset of Severe Hypertrophic Cardiomyopathy
Decrease in mortality, morbidity seen with trametinib for children with RASopathy-associated hypertrophic cardiomyopathy
Shorter Treatment Regimens Recommended for Tuberculosis
Four-month regimen recommended for drug-susceptible TB and six-month regimen recommended for drug-resistant TB
FDA Adds Warning Label to RSV Vaccines Abrysvo and Arexvy
Postmarketing observation shows increased risk for Guillain-Barré syndrome for 42 days postvaccination
Some Maternal Medications Lower Levels of Protein, Fat in Breastmilk
Significantly lower protein levels seen with SSRIs and steroids; mean fat lower for mothers with other anti-inflammatory drugs
15.4 Percent of 0- to 35-Month-Olds Receive Invalid Vaccine Dose
Of children with minimum age or minimum interval invalid dose, almost 50 percent receive extra doses
Nasal Epithelial Gene Expression IDs Asthma Endotypes in Children
Nasal transcriptomic profiles consistent with T2-high, T17-high, and T2-low/T17-low endotypes occurred in similar proportions across three studies
Oral Glucose-Lowering Agents Potential Alternatives to Insulin for Gestational Diabetes
Treatment of gestational diabetes with metformin, and glyburide if needed, does not meet noninferiority criteria versus insulin
Preexisting Neuroanatomical Variability Linked to Pediatric Substance Use
Most associations, including thinner prefrontal cortex and greater whole brain volume, precede substance use initiation
Early-Life Infection Burden Linked to Risk for Later Infections
Risk increased for later moderate-to-severe infections and systemic antibiotic treatments
