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Scientists have issued a comprehensive map of human epigenomes -- the range of chemical and structural shifts that determine how genes govern health. The group published the new map online Feb. 18 in Nature

‘Most Comprehensive Map’ of Human Epigenomes Presented

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Result of years of work by an international consortium of researchers
For sorafenib-treated patients with hepatitis B virus-related hepatocellular carcinoma

Antiviral Tx Improves Survival in Sorafenib-Treated HBV-HCC

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Antiviral therapy with nucleoside analogues linked to improved overall survival
For patients with metastatic colorectal cancer

Wide Variation in Hospital Tx Patterns for Metastatic CRC

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Use of metastatic site surgery, multiagent chemo increases as hospitals' volume of services increases
Observation is increasingly being used among men with low-risk prostate cancer who are young and healthy enough for treatment

Observation Increasingly Used in Younger Men With Prostate CA

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From 2004 to 2009, marked increase in observation among men with low-risk disease
A novel oral substrate reduction therapy

Eliglustat Safely Reverses Manifestations of Gaucher’s

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Significant improvement in spleen volume for untreated adults with type 1 disease
For postmenopausal women

Lycopene Inversely Linked to Renal Cell Carcinoma Risk

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Findings from 96,196 postmenopausal women enrolled in Women's Health Initiative
Considerable practice variation exists among surgeons at a high-volume academic center when selecting patients with prostate cancer to undergo radical prostatectomy

Considerable Surgeon-Level Variation in Radical Prostatectomy

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Variation exists at high-volume center when selecting patients with low-risk prostate cancer
In an environment where patients are increasingly aware of the costs of health care

High Deductible Plans Factor Into Physician-Patient Relationship

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Physicians may want to be proactive by detailing costs and options for patients
Fear of corporate defamation lawsuits should not prevent medical journals from investigating corporate products

Medical Journals Should Not Be Swayed by Fear of Libel Lawsuits

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Fear of corporate defamation lawsuits should not prevent examination of corporate products
From 1980 to 2010 the Latino physician shortage worsened

Latino Physician Shortage Has Worsened Since 1980

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Decrease in Latino physician rate per 100,000 of the Latino population from 1980 to 2010