Here are what the editors at HealthDay consider to be the most important developments in Critical Care for April 2020. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Symptomatic Health Care Staff in U.K. Screened for COVID-19
THURSDAY, April 30, 2020 (HealthDay News) — Screening symptomatic health care workers for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is feasible during the pandemic, according to a research letter published online April 22 in The Lancet.
Remdesivir May Accelerate Recovery From Severe COVID-19
THURSDAY, April 30, 2020 (HealthDay News) — Remdesivir may speed time to clinical improvement for patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, although results are conflicting, according to a study published online April 29 in The Lancet and press releases issued regarding a National Institutes of Health (NIH)-sponsored study.
Men Have More Serious Disease, Higher Death Rate From COVID-19
THURSDAY, April 30, 2020 (HealthDay News) — For patients with COVID-19, male gender is associated with worse outcomes, independent of age, according to a study published online April 29 in Frontiers in Public Health.
Large-Vessel Stroke Described in Young Adults With COVID-19
THURSDAY, April 30, 2020 (HealthDay News) — Cases of large-vessel stroke in individuals younger than 50 years are described in patients with COVID-19 in a case report published online April 28 in the New England Journal of Medicine.
Almost All COVID-19 Patients Have Diminished Sense of Smell
WEDNESDAY, April 29, 2020 (HealthDay News) — Quantitative smell testing shows that decreased smell function is a major marker for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, according to a study published online April 17 in the International Forum of Allergy & Rhinology.
Guidelines Recommended for ECMO Use in Setting of Pandemic
WEDNESDAY, April 29, 2020 (HealthDay News) — Hospitals should have a formal plan to respond to the increasing need for extracorporeal membrane oxygenation (ECMO) in the setting of a pandemic such as COVID-19, according to a study published online April 15 in the Annals of the American Thoracic Society.
Many Health Care Workers Face Risk for Poor Outcomes With COVID-19
WEDNESDAY, April 29, 2020 (HealthDay News) — More than one-quarter of health care workers with patient contact are at risk for poor outcomes from COVID-19, according to a study published online April 28 in the Annals of Internal Medicine.
David Shulkin, M.D., on COVID-19 Financial Consequences for Health Care System
MONDAY, April 27, 2020 (HealthDay News) — Health care organizations are facing hard financial decisions amid the COVID-19 pandemic, but an end is in sight as some are beginning to slowly open back up around the country, according to David Shulkin, M.D. Shulkin, who served as ninth secretary for Veterans Affairs and is former president and CEO of Beth Israel Medical Center in New York, spoke with HealthDay during a live stream on the HealthDay YouTube channel and live blog.
Primary PCI Remains Standard of Care for STEMI During COVID-19
WEDNESDAY, April 29, 2020 (HealthDay News) — Primary percutaneous coronary intervention (PCI) remains the standard of care for patients with ST-elevation myocardial infarction (STEMI) during the COVID-19 pandemic, according to a consensus statement published online April 20 in the Journal of the American College of Cardiology.
Thromboembolic Complications in COVID-19 Discussed
WEDNESDAY, April 29, 2020 (HealthDay News) — Prevention, diagnosis, and therapeutic management of thromboembolic complications in COVID-19 are discussed in a report published online April 23 in Radiology.
45.4 Percent of U.S. Adults at Risk for Complications With COVID-19
TUESDAY, April 28, 2020 (HealthDay News) — An estimated 45.4 percent of U.S. adults may have an increased risk for COVID-19 complications due to chronic conditions, according to a study published in the August issue of Emerging Infectious Diseases.
Recommendations Developed for Anesthesia Use During COVID-19
TUESDAY, April 28, 2020 (HealthDay News) — Recommendations have been developed for use of anesthesia during the COVID-19 pandemic, according to a joint statement issued by the American Society of Regional Anesthesia and Pain Medicine and the European Society of Regional Anesthesia and Pain Therapy.
Adding High-Dose Chloroquine Not Advised for Severe COVID-19
TUESDAY, April 28, 2020 (HealthDay News) — High-dosage chloroquine diphosphate (CQ) has potential safety hazards when used as adjunctive therapy for patients hospitalized with severe COVID-19, according to a study published online April 24 in JAMA Network Open.
High Rate of Pulmonary Embolism Found for Patients With COVID-19
TUESDAY, April 28, 2020 (HealthDay News) — COVID-19 is associated with a high rate of pulmonary embolism, according to two research letters published online April 23 in Radiology.
Abstract/Full Text — Leonard-Lorant (subscription or payment may be required)
Abstract/Full Text — Grillet (subscription or payment may be required)
Patients Aged 60 to 69 Most Often Hospitalized With COVID-19
TUESDAY, April 28, 2020 (HealthDay News) — Persons aged 60 to 69 years with COVID-19 are the most commonly hospitalized, according to a research letter published online April 24 in the Journal of the American Medical Association.
Neurologic Features Tied to ARDS in Severe COVID-19 Described
MONDAY, April 27, 2020 (HealthDay News) — Acute respiratory distress syndrome (ARDS) due to COVID-19 is associated with neurologic features, including encephalopathy, agitation, and confusion, according to a letter to the editor published online April 15 in the New England Journal of Medicine.
WHO: No Evidence COVID-19 Survivors Cannot Be Reinfected
MONDAY, April 27, 2020 (HealthDay News) — There is “no evidence” that people who have recovered from COVID-19 cannot be reinfected with the severe acute respiratory syndrome coronavirus 2, according to the World Health Organization.
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More Information: CDC
Direct Medical Costs of COVID-19 Infection Are Considerable
MONDAY, April 27, 2020 (HealthDay News) — A single symptomatic COVID-19 infection results in direct medical costs of $3,045 in the United States, according to a study published online April 23 in Health Affairs.
Recommendations Issued for Imaging Use in Pediatric COVID-19
MONDAY, April 27, 2020 (HealthDay News) — In an international expert consensus statement, published online April 23 in Radiology: Cardiothoracic Imaging, recommendations are presented for chest imaging in pediatric COVID-19 patient management.
Physician’s Briefing Weekly Coronavirus Roundup
Here is what the editors at Physician’s Briefing chose as the most important COVID-19 developments for you and your practice for the week of April 20 to 24, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.
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HTN, Obesity, Diabetes Common in U.S. COVID-19 Patients
FRIDAY, April 24, 2020 (HealthDay News) — The most common comorbidities among patients hospitalized with COVID-19 in the New York City area are hypertension, obesity, and diabetes, according to a study published online April 22 in the Journal of the American Medical Association.
Premature Posting of Remdesivir Findings Were ‘Inconclusive’
FRIDAY, April 24, 2020 (HealthDay News) — Inconclusive findings from a study investigating the antiviral drug remdesivir as a treatment for COVID-19 were posted to the World Health Organization website “prematurely,” drug maker Gilead Sciences said Thursday.
CNN Article
FDA Warns About Treating COVID-19 With Unproven Drugs
FRIDAY, April 24, 2020 (HealthDay News) — Malaria drugs touted by some as potential “game changers” against COVID-19 are actually too dangerous for general use, the U.S. Food and Drug Administration warned Americans on Friday.
SARS-CoV-2 Stays in Respiratory Samples Longer in Severely Ill
FRIDAY, April 24, 2020 (HealthDay News) — The median duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA is significantly longer in the respiratory samples of patients with severe versus mild disease, according to a study published online April 21 in The BMJ.
Low Doses of Bevacizumab Tested for Retinopathy of Prematurity
FRIDAY, April 24, 2020 (HealthDay News) — For treatment of retinopathy of prematurity (ROP), 0.004 mg may be the lowest effective dose of bevacizumab, according to a study published online April 23 in JAMA Ophthalmology.
Survey Finds Anesthesiologists Prepared for COVID-19 Patients
FRIDAY, April 24, 2020 (HealthDay News) — Anesthesiologists on the front lines of treating surgical COVID-19 patients in Turkey are generally knowledgeable about airway management, according to the results of a national survey published online April 6 in Surgical Infections.
COVID-19 Outcomes Worse With Diabetes, Hyperglycemia
FRIDAY, April 24, 2020 (HealthDay News) — Diabetes and/or uncontrolled hyperglycemia occur frequently among hospitalized patients with COVID-19 and are associated with worse outcomes, according to a study accepted for publication in the Journal of Diabetes Science and Technology.
‘Health Force’ to Combat Pandemic Proposed by U.S. Senators
THURSDAY, April 23, 2020 (HealthDay News) — A bill to create a “Health Force” to help combat the U.S. COVID-19 outbreak has been announced by two Democratic senators.
NBC News Article
White House Announces Payment Plan for Uninsured COVID-19 Patients
THURSDAY, April 23, 2020 (HealthDay News) — A plan to begin paying hospitals and doctors who treat uninsured COVID-19 patients was announced by U.S. Health and Human Services Secretary Alex Azar on Wednesday.
AP News Article
ACEIs/ARBs Not Linked to Severity or Mortality of COVID-19
THURSDAY, April 23, 2020 (HealthDay News) — For patients with hypertension hospitalized with COVID-19 infections, angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs) are not associated with the severity or mortality of COVID-19, according to a brief report published online April 23 in JAMA Cardiology.
Mild, No Symptoms Seen for Most Children With SARS-CoV-2 Infection
THURSDAY, April 23, 2020 (HealthDay News) — Most children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have mild respiratory symptoms or are asymptomatic, according to a review published online April 22 in JAMA Pediatrics.
Lopinavir/Ritonavir, Umifenovir Ineffective for Mild COVID-19
THURSDAY, April 23, 2020 (HealthDay News) — For patients hospitalized with mild/moderate COVID-19, lopinavir/ritonavir (LPV/r) or umifenovir (Arbidol) monotherapy offers little benefit, according to a study published online April 17 in Med.
AAD Establishes Registry for Skin Manifestations of COVID-19
THURSDAY, April 23, 2020 (HealthDay News) — A registry has been created for reporting skin manifestations of COVID-19 following reports of patients presenting with skin conditions, including findings outlined in a letter to the editor published online March 26 in the Journal of the European Academy of Dermatology and Venereology.
Chronic Conditions, Obesity Common in Fatal Cases of EVALI
THURSDAY, April 23, 2020 (HealthDay News) — Chronic conditions, including asthma, mental health conditions, and obesity, are common among fatal cases of e-cigarette, or vaping, product use-associated lung injury (EVALI), according to a study published in the April 23 issue of the New England Journal of Medicine.
Hydroxychloroquine Seems Not to Cut Ventilator Use in COVID-19
WEDNESDAY, April 22, 2020 (HealthDay News) — There is no evidence that use of hydroxychloroquine alone (HC) or with azithromycin (HC+AZ) reduces the risks for mechanical ventilation or death from any cause in patients hospitalized with COVID-19, according to a study that has not yet been peer reviewed and was posted online April 21 at medRxiv.org.
Rapid COVID-19 Test Can Produce False Negatives
WEDNESDAY, April 22, 2020 (HealthDay News) — A widely used rapid COVID-19 test can produce false negatives if a certain solution is used to move or store patients’ samples, the test’s maker said.
CNN Article
Expert Panel: There Are No Proven Drug Treatments for COVID-19
WEDNESDAY, April 22, 2020 (HealthDay News) — There is no proven drug treatment for COVID-19 patients, according to a panel of experts convened by the U.S. National Institute of Allergy and Infectious Diseases.
The New York Times Article
ST-Segment Elevation Described in Patients With COVID-19
WEDNESDAY, April 22, 2020 (HealthDay News) — For patients with COVID-19 who have ST-segment elevation, indicating potential acute myocardial infarction, there is considerable variability in presentation, and prognosis is poor, according to a letter to the editor published online April 17 in the New England Journal of Medicine.
Obesity Ups Risk for COVID-19 Severity
WEDNESDAY, April 22, 2020 (HealthDay News) — There is a high frequency of obesity among patients admitted to intensive care for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), according to a study published online April 9 in Obesity.
Scoring System Helps Guide Surgical Care During COVID-19
WEDNESDAY, April 22, 2020 (HealthDay News) — A scoring system for medically necessary time-sensitive (MeNTS) procedures can facilitate decision making and triage in the setting of COVID-19, according to a study published online April 9 in the Journal of the American College of Surgeons.
LA County COVID-19 Infections Far Exceed Number of Confirmed Cases
TUESDAY, April 21, 2020 (HealthDay News) — An early analysis of antibody testing from Los Angeles County reveals a COVID-19 infection rate that is up to 55 times the number of confirmed COVID-19 cases.
FDA Authorizes COVID-19 Test That Uses Samples Collected at Home
TUESDAY, April 21, 2020 (HealthDay News) — The U.S. Food and Drug Administration has approved emergency use of the first COVID-19 test that enables patients to take samples at home.
176,190 U.S. Children Estimated to Have SARS-CoV-2 by April 6, 2020
TUESDAY, April 21, 2020 (HealthDay News) — About 176,190 children nationwide were estimated to be infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by April 6, 2020, according to a study published online April 16 in the Journal of Public Health Management & Practice.
Expanding Symptom Screening Criteria Can Up COVID-19 Detection
TUESDAY, April 21, 2020 (HealthDay News) — Expanding COVID-19 symptom screening criteria to include myalgias and chills could identify more health care personnel (HCP) with the illness, according to a research letter published online April 17 in the Journal of the American Medical Association.
Coinfection With SARS-CoV-2, Other Respiratory Pathogens ID’d
TUESDAY, April 21, 2020 (HealthDay News) — About 20 percent of specimens positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are positive for other respiratory pathogens, according to a research letter published online April 15 in the Journal of the American Medical Association.
Cardiac Cath Lab STEMI Activations Drop During Pandemic
TUESDAY, April 21, 2020 (HealthDay News) — During the COVID-19 pandemic, there has been a 38 percent reduction in U.S. cardiac catheterization laboratory ST-segment elevation myocardial infarction (STEMI) activations, according to a research letter published online April 10 in the Journal of the American College of Cariology.
Lab Protocol Failures Led to Ineffective COVID-19 Tests From CDC
MONDAY, April 20, 2020 (HealthDay News) — The first COVID-19 tests in the United States were ineffective due to poor laboratory practices at the U.S. Centers for Disease Control and Prevention, the U.S. Food and Drug Administration said.
The New York Times Article
Public Health Measures Cut COVID-19 Transmission in Hong Kong
MONDAY, April 20, 2020 (HealthDay News) — Public health measures implemented to suppress local transmission of COVID-19 in Hong Kong were associated with reduced transmission of COVID-19 and influenza, according to a study published online April 17 in The Lancet Public Health.
COVID-19 Patients May Require ENT Consults for Varied Reasons
MONDAY, April 20, 2020 (HealthDay News) — Patients with COVID-19 may require ear, nose, and throat (ENT) consultations for many reasons, including tracheotomy, and protective strategies can prevent infection of otolaryngologists, according to a case series study accepted for publication in Otolaryngology-Head and Neck Surgery.
Diabetes Increases Risk for Poorer Prognosis in COVID-19
MONDAY, April 20, 2020 (HealthDay News) — Diabetes may contribute to more severe symptoms, rapid progression, and poorer prognosis in patients infected with COVID-19, according to a study published online March 31 in Diabetes Metabolism Research and Reviews.
Benefit of Social Distancing Outweighs Economic Impact
MONDAY, April 20, 2020 (HealthDay News) — The economic benefits of lives saved through social distancing substantially outweigh the value of the projected losses to the U.S. economy, according to a study to be published in a forthcoming issue of the Journal of Benefit-Cost Analysis.
Physician’s Briefing Weekly Coronavirus Roundup
Here is what the editors at Physician’s Briefing chose as the most important COVID-19 developments for you and your practice for the week of April 13 to 17, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.
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Insomnia Common Among Medical Staff During COVID-19 in China
FRIDAY, April 17, 2020 (HealthDay News) — More than one-third of medical staff members in hospitals during the coronavirus disease 2019 (COVID-19) outbreak in China reported insomnia symptoms, according to a study published online April 14 in Frontiers in Psychiatry.
CDC Looks at Transmission of COVID-19 to Health Care Workers
FRIDAY, April 17, 2020 (HealthDay News) — Transmission of coronavirus disease 2019 (COVID-19) to health care personnel (HCP) is explored in two studies published in the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.
Abstract/Full Text – Heinzerling
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Incidence of SARS-CoV-2 Infection Stable in Iceland
FRIDAY, April 17, 2020 (HealthDay News) — In Iceland, the incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was stable through 20 days of screening, according to a study published online April 14 in the New England Journal of Medicine.
Asthma Not Common in COVID-19 Patients Who Have Died
FRIDAY, April 17, 2020 (HealthDay News) — Asthma is not among the top 10 chronic health problems in people who have died from coronavirus disease 2019 (COVID-19) in New York state, even though many health experts have warned that people with asthma are at increased risk for severe illness if they get COVID-19.
The New York Times Article
Scientists Design Protective Respirator for Health Care Workers
THURSDAY, April 16, 2020 (HealthDay News) — With protective gear in short supply, Duke University researchers say they have designed a much-needed respirator for health care workers battling coronavirus disease 2019 (COVID-19).
IDSA Issues Rapid Guidelines for Treatment of COVID-19
FRIDAY, April 17, 2020 (HealthDay News) — In rapid guidelines issued by the Infectious Diseases Society of America (IDSA), recommendations are presented for the treatment and management of coronavirus disease 2019 (COVID-19).
Chest X-Ray Findings Normal for Many Confirmed COVID-19 Cases
FRIDAY, April 17, 2020 (HealthDay News) — Most patients presenting to urgent care centers with confirmed coronavirus disease 2019 (COVID-19) have normal or mildly abnormal findings on chest X-rays (CXRs), according to a study published online April 14 in the Journal of Urgent Care Medicine.
Risk for Severe COVID-19 May Be Up in People With COPD, Smokers
FRIDAY, April 17, 2020 (HealthDay News) — Active cigarette smokers and individuals with chronic obstructive pulmonary disease (COPD) have up-regulation of angiotensin converting enzyme II (ACE-2) expression in the lower airways, which could explain the increased risk for severe COVID-19 in these subpopulations, according to a study published online April 8 in the European Respiratory Journal.
Recurrent Winter Outbreaks of SARS-CoV-2 Projected
THURSDAY, April 16, 2020 (HealthDay News) — Recurrent winter outbreaks of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) are projected to occur after the initial pandemic wave, according to a study published online April 14 in Science.
Sharp Drop in Demand Seen for COVID-19 Tests at Private Labs
THURSDAY, April 16, 2020 (HealthDay News) — There has been such a drop in demand for coronavirus disease 2019 (COVID-19) tests at private labs in the United States that they have “considerable” unused capacity and can test more patients with less severe symptoms, the American Clinical Laboratory Association (ACLA) says.
NBC News Article
FDA Urges COVID-19 Survivors to Donate Plasma
THURSDAY, April 16, 2020 (HealthDay News) — The U.S. Food and Drug Administration is asking Americans who have recovered from coronavirus disease 2019 (COVID-19) to donate their blood plasma to help fight the pandemic.
CRISPR-Based Test Can Diagnose COVID-19 in Under 60 Minutes
THURSDAY, April 16, 2020 (HealthDay News) — Researchers say they have developed a low-cost swab test that can diagnose coronavirus disease 2019 (COVID-19) infections in about 45 minutes.
Guidance Developed for Treating Cardiac Arrest During COVID-19
THURSDAY, April 16, 2020 (HealthDay News) — In a document entitled “Interim Guidance for Basic and Advanced Life Support in Adults, Children, and Neonates With Suspected or Confirmed COVID-19,” published online April 9 in Circulation, recommendations are presented for treating victims of cardiac arrest during the coronavirus disease 2019 (COVID-19) pandemic.
Survey Shows Lack of COVID-19 Concern Even Among Those at Risk
WEDNESDAY, April 15, 2020 (HealthDay News) — Many individuals at greater risk for coronavirus disease 2019 (COVID-19) complications did not believe the virus would affect them at the beginning of Chicago’s outbreak, according to a study published online April 9 in the Annals of Internal Medicine.
Obesity Is Risk Factor for COVID-19 Hospital Admission in <60s
WEDNESDAY, April 15, 2020 (HealthDay News) — Obesity is associated with admission to the hospital for coronavirus disease 2019 (COVID-19) patients, according to a study published online April 9 in Clinical Infectious Diseases and a study not yet peer reviewed and posted on medRxiv.org.
Abstract/Full Text – Lighter (subscription or payment may be required)
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Compliance With Self-Isolation Influenced by Compensation
WEDNESDAY, April 15, 2020 (HealthDay News) — In the era of coronavirus disease 2019 (COVID-19), compliance with self-isolation is influenced by compensation, with very high compliance seen when compensation for lost wages is assured, according to a report published online April 9 in Health Affairs.
SARS-CoV-2 Contamination of Air, Surfaces Examined in ICU, Wards
WEDNESDAY, April 15, 2020 (HealthDay News) — Considerable severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) contamination of air and object surfaces is reported in intensive care units (ICUs) and general coronavirus disease 2019 (COVID-19) wards (GW), according to a study published online April 10 in Emerging Infectious Diseases, a publication of the U.S. Centers for Disease Control and Prevention.
Public Health Interventions Improved COVID-19 Control in Wuhan
WEDNESDAY, April 15, 2020 (HealthDay News) — Multifaceted public health interventions improved control of the coronavirus disease 2019 (COVID-19) outbreak in Wuhan, China, according to a study published online April 10 in the Journal of the American Medical Association.
Intubation Initiated in One in Five Who Died of COVID-19 in China
WEDNESDAY, April 15, 2020 (HealthDay News) — Many patients who died from coronavirus disease 2019 (COVID-19) in China may have had delayed intubation, according to a research letter published online April 10 in JAMA Network Open.
Common Coronaviruses Are Highly Seasonal
WEDNESDAY, April 15, 2020 (HealthDay News) — Common coronaviruses circulate seasonally, according to a study published online April 4 in the Journal of Infectious Diseases.
Smell, Taste Impairment Linked to COVID-19 Positivity
TUESDAY, April 14, 2020 (HealthDay News) — Smell and taste impairment are strongly associated with coronavirus disease 2019 (COVID-19) positivity, according to a study published online April 12 in the International Forum of Allergy & Rhinology.
Review: Quarantine Effective for Reducing Infection, Death
TUESDAY, April 14, 2020 (HealthDay News) — Quarantine is effective for reducing the number of people infected and deaths from coronavirus disease 2019 (COVID-19), according to a review published online April 8 in the Cochrane Database of Systematic Reviews.
CDC: Public Policy Measures Important for Social Distancing
TUESDAY, April 14, 2020 (HealthDay News) — Community mobility in four metropolitan areas decreased with the introduction of public policy measures supporting social distancing, which could help slow the spread of coronavirus disease 2019 (COVID-19), according to research published in the April 13 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.
U.S. Government Says COVID-19 Antibody Tests Must Be Free
TUESDAY, April 14, 2020 (HealthDay News) — Health insurers and Medicaid must provide free coverage for tests to detect coronavirus 2019 (COVID-19) antibodies in people who have been infected, the federal government says.
CBS News Article
Johns Hopkins University
First Saliva Test for COVID-19 Approved by FDA
TUESDAY, April 14, 2020 (HealthDay News) — The first saliva test for coronavirus 2019 (COVID-19) was approved Monday by the U.S. Food and Drug Administration.
Medical Masks May Be Sufficient During COVID-19 Routine Care
TUESDAY, April 14, 2020 (HealthDay News) — Use of medical masks, such as surgical or procedural masks, does not increase the risk for viral infection or respiratory illness, and their use may serve as a protective measure in instances of N95 respirator shortages, according to the results of a meta-analysis published online April 4 in Influenza and Other Respiratory Viruses.
COVID-19 RNA Detectable in Patient Fecal Matter
TUESDAY, April 14, 2020 (HealthDay News) — The presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA is detectable in the feces of COVID-19 patients and remains even after negative conversion in pharyngeal swabs, according to a study published online April 3 in the Journal of Medical Virology.
First Wave of COVID-19 Abated With Control Measures in China
TUESDAY, April 14, 2020 (HealthDay News) — Interventions implemented in China interrupted coronavirus disease 2019 (COVID-19) transmission in all areas outside of Hubei, and low transmissibility can be maintained by monitoring the instantaneous effective reproduction number (Rt), according to a study published online April 8 in The Lancet.
Model Forecasts When COVID-19 Demand Will Exceed Capacity
TUESDAY, April 14, 2020 (HealthDay News) — The COVID-19 Hospital Impact Model (CHIME), a publicly available tool, can help hospitals predict the timing of saturated capacity, according to a report published online April 7 in the Annals of Internal Medicine.
Physicians Report Expanding Use of Off-Label COVID-19 Treatments
MONDAY, April 13, 2020 (HealthDay News) — Hydroxychloroquine usage is expanding globally to treat coronavirus 2019 (COVID-19), although plasma from recovered patients is perceived as more effective than hydroxychloroquine, according to a report released by Sermo.
COVID-19 Antibody Tests Underway in California
MONDAY, April 13, 2020 (HealthDay News) — Large-scale studies of tests to check for antibodies to coronavirus 2019 (COVID-19) are underway in California. The findings from this research could help the United States develop strategies to get people back to work and restart the economy.
NBC News Article
Chloroquine COVID-19 Trial Stopped After Patient Deaths
MONDAY, April 13, 2020 (HealthDay News) — A study of chloroquine in coronavirus 2019 (COVID-19) patients was halted due to potentially deadly side effects.
The New York Times Article
Remdesivir May Improve Oxygen-Support Class in Severe COVID-19
MONDAY, April 13, 2020 (HealthDay News) — Improvement in oxygen support status was observed in 68 percent of patients hospitalized with severe coronavirus disease 2019 (COVID-19) who received compassionate use of remdesivir, according to a study published online April 10 in the New England Journal of Medicine.
CDC Report Details Geographic Variation in U.S. COVID-19 Cases, Deaths
MONDAY, April 13, 2020 (HealthDay News) — There is variation in the cumulative incidence of coronavirus disease 2019 (COVID-19) across jurisdictions in the United States, according to research published in the April 10 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.
Recommendations Issued for Use of Imaging in Adults With COVID-19
MONDAY, April 13, 2020 (HealthDay News) — In a multinational consensus statement from the Fleischner Society, published online April 7 in Radiology, recommendations are presented for use of imaging in patients with coronavirus disease 2019 (COVID-19).
Mechanical Ventilation Needed by Most COVID-19 Patients in ICU
MONDAY, April 13, 2020 (HealthDay News) — Most patients with coronavirus disease 2019 (COVID-19) requiring treatment in an intensive care unit (ICU) require mechanical ventilation, according to a study published online April 6 in the Journal of the American Medical Association.
Guidance Issued for Infants Born to Mothers With COVID-19
MONDAY, April 13, 2020 (HealthDay News) — In an initial guidance document issued by the American Academy of Pediatrics, recommendations are presented for the management of infants born to mothers with suspected or confirmed coronavirus disease 2019 (COVID-19).
Physician’s Briefing Weekly Coronavirus Roundup
Here is what the editors at Physician’s Briefing chose as the most important COVID-19 developments for you and your practice for the week of April 6 to 10, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.
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Contact Tracing ID’d Large Multifamily COVID-19 Cluster in Chicago
FRIDAY, April 10, 2020 (HealthDay News) — One index patient with COVID-19 and only mild symptoms attended two family gatherings and likely triggered a chain of transmission that included 15 other confirmed and probable cases with three deaths, according to research published in the April 8 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.
Neurologic Effects Seen in a Third of Hospitalized COVID-19 Patients
FRIDAY, April 10, 2020 (HealthDay News) — Neurologic manifestations are common among hospitalized patients with COVID-19, according to a study published online April 10 in JAMA Neurology.
Temperature, UV Radiation Not Linked to Incidence of COVID-19
FRIDAY, April 10, 2020 (HealthDay News) — Ambient temperature and ultraviolet (UV) radiation are not associated with the cumulative incidence rate or basic reproduction number (R0) of coronavirus disease 2019 (COVID-19), according to a research letter published online April 8 in the European Respiratory Journal.
FDA Approves New Way to Decontaminate N95 Face Masks
FRIDAY, April 10, 2020 (HealthDay News) — The second emergency use authorization to decontaminate N95 face masks and equivalents for reuse by hospital health care workers has been issued by the U.S. Food and Drug Administration.
Anxiety Up for Nonmedical Health Care Workers Versus Those on Front Lines
FRIDAY, April 10, 2020 (HealthDay News) — Non-medically trained health care workers caring for patients with coronavirus disease 2019 (COVID-19) have an increased prevalence of anxiety compared with medically trained health care workers, according to a research letter published online April 6 in the Annals of Internal Medicine.
Face Masks Offer Slight Protective Effect From Flu-Like Illness
FRIDAY, April 10, 2020 (HealthDay News) — Wearing face masks could be slightly protective against primary infection with influenza-like illness from casual community contact, according to a review that has not yet been peer reviewed and was posted online April 6 at medRxiv.org.
Current Models for COVID-19 Diagnosis, Prognosis Unreliable
FRIDAY, April 10, 2020 (HealthDay News) — Novel coronavirus (COVID-19)-related models that are published in the literature are poorly reported and at high risk for bias, raising concern that their predictions could be unreliable when applied in daily practice, according to a review published online April 7 in The BMJ.
Doctors Report on Four COVID-19 Infections in Newborns in China
FRIDAY, April 10, 2020 (HealthDay News) — Compared with adults, symptoms of COVID-19 in newborn babies are milder and outcomes are less severe, according to a research letter published online April 8 in the European Respiratory Journal.
Clinical Trial Underway to Test Nitric Oxide in COVID-19 Patients
THURSDAY, April 9, 2020 (HealthDay News) — Doctors at the University of Alabama at Birmingham (UAB) are enrolling patients in an international clinical trial to find out if inhaled nitric oxide benefits those with novel coronavirus (COVID-19) who have severely damaged lungs.
Another COVID-19 Vaccine Trial Begins in the United States
THURSDAY, April 9, 2020 (HealthDay News) — Another clinical trial of an experimental vaccine for the novel coronavirus 2019 (COVID-19) has been launched by U.S. researchers.
AP News Article
FDA Warns of False Claims That Chlorine Dioxide Can Treat COVID-19
THURSDAY, April 9, 2020 (HealthDay News) — A warning letter has been sent to a company marketing fraudulent and dangerous chlorine dioxide products for the prevention and treatment of the novel coronavirus (COVID-19), the U.S. Food and Drug Administration says.
COVID-19 Came to New York City From Europe, Not Asia
THURSDAY, April 9, 2020 (HealthDay News) — The novel coronavirus (COVID-19) has been circulating in New York City for longer than previously believed and most cases can be traced back to Europe, new research reveals.
NIH Launches Clinical Trial of Hydroxychloroquine for COVID-19
THURSDAY, April 9, 2020 (HealthDay News) — A clinical trial to assess the antimalarial drug hydroxychloroquine as a treatment for adults with the novel coronavirus (COVID-19) is now underway, the U.S. National Institutes of Health said Thursday.
Older Adults, Men, Preexisting Conditions Tied to COVID-19 Death
THURSDAY, April 9, 2020 (HealthDay News) — Researchers have identified the most common clinical characteristics among 109 patients out of 1,017 with confirmed novel coronavirus (COVID-19) pneumonia who died of COVID-19-related pneumonia in Wuhan, China; their findings were published online April 7 in the Annals of the American Thoracic Society.
Convalescent Plasma Treatment Promising in Severe COVID-19
THURSDAY, April 9, 2020 (HealthDay News) — One dose of convalescent plasma (CP) therapy is well tolerated and can potentially improve clinical symptoms in severe cases with coronavirus disease 2019 (COVID-19), according to a study published online April 6 in the Proceedings of the National Academy of Sciences.
ATS Provides Interim Guidance for Management of COVID-19
THURSDAY, April 9, 2020 (HealthDay News) — In a guidance document issued by the American Thoracic Society, interim recommendations are presented for management of coronavirus disease 2019 (COVID-19).
HHS Report Looks at Hospital Experiences With COVID-19
THURSDAY, April 9, 2020 (HealthDay News) — A report issued by the U.S. Department of Health and Human Services Office of Inspector General provides a national snapshot of hospital experiences in response to the coronavirus disease 2019 (COVID-19).
Children With COVID-19 Do Not Always Have Cough, Fever
WEDNESDAY, April 8, 2020 (HealthDay News) — Children with coronavirus disease 2019 (COVID-19) have symptoms of fever, cough, or shortness of breath less often than adults with the disease, according to research published in the April 6 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.
CDC Removes Prescribing Guidelines for Antimalarial Drugs
WEDNESDAY, April 8, 2020 (HealthDay News) — Guidelines for doctors on how to prescribe two antimalarial drugs that some believe may treat the novel coronavirus (COVID-19) are no longer available on the U.S. Centers for Disease Control and Prevention website.
COVID-19 Killing Two Times More Men Than Women in NYC
WEDNESDAY, April 8, 2020 (HealthDay News) — The novel coronavirus (COVID-19) death rate in New York City is two times higher among men than among women, and men also have higher rates of infection and hospitalization, new data show.
Surgical, Cotton Masks Not Effective for Filtering SARS-CoV-2
WEDNESDAY, April 8, 2020 (HealthDay News) — For patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), neither surgical nor cotton masks effectively filter SARS-CoV-2 during coughs, according to a research letter published online April 6 in the Annals of Internal Medicine.
Guidelines Developed for COVID-19 Patients in ICU
WEDNESDAY, April 8, 2020 (HealthDay News) — In guidelines issued by the international Surviving Sepsis Campaign initiative, published in Critical Care Medicine and Intensive Care Medicine, recommendations are presented for the management of novel coronavirus disease 2019 (COVID-19) patients in the intensive care unit (ICU).
Compliance Higher if Stay-at-Home Extensions Are Shorter Than Thought
TUESDAY, April 7, 2020 (HealthDay News) — When hypothetical stay-at-home orders in response to COVID-19 are extended longer than expected, people become less willing to increase self-isolation efforts, according to a working paper released by the National Bureau of Economic Research.
Side Effects Seen With Use of Chloroquine Against COVID-19
TUESDAY, April 7, 2020 (HealthDay News) — The use of the antimalarial drug chloroquine to treat COVID-19 patients has been halted at several Swedish hospitals due to reported side effects such as cramps and loss of peripheral vision. Sahlgrenska University Hospital is one of those facilities. It stopped the use of chloroquine in the treatment of COVID-19 about two weeks ago.
Newsweek Article
Johns Hopkins University
Most COVID-19 Fatalities Are Men Over 50 With Chronic Disease
TUESDAY, April 7, 2020 (HealthDay News) — Most fatal cases of coronavirus disease 2019 (COVID-19) occur in men aged older than 50 years with noncommunicable chronic diseases, according to a study published online April 3 in the American Journal of Respiratory and Critical Care Medicine.
School Closures Could Further Complicate COVID-19 Effort
TUESDAY, April 7, 2020 (HealthDay News) — Potential contagion prevention from school closures needs to be weighed against the potential loss of health care workers due to child care obligations during the coronavirus disease 2019 (COVID-19) pandemic, according to a study published online April 3 in The Lancet Public Health.
FDA Authorizes Use of Chinese-Approved Masks in United States
MONDAY, April 6, 2020 (HealthDay News) — Emergency use authorization of protective masks that do not meet American standards has been announced by the U.S. Food and Drug Administration.
More Information: FDA
More Information: CDC
Johns Hopkins University
Majority of Physicians Report Serious Concerns About COVID-19
MONDAY, April 6, 2020 (HealthDay News) — According to a national survey conducted by Harvard Medical School, the RAND Corporation, and Doximity, practicing physicians currently report substantial concerns about supplies, the government response, and availability of testing amid the COVID-19 pandemic.
Sentinel Surveillance Can Help Monitor Epidemiology of COVID-19
MONDAY, April 6, 2020 (HealthDay News) — Rapid sentinel surveillance can help monitor the epidemiology of coronavirus disease 2019 (COVID-19), according to research published in the April 3 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.
Comorbidity, Age, Time to Treatment Linked to COVID-19 Progression
MONDAY, April 6, 2020 (HealthDay News) — Factors associated with coronavirus disease 2019 (COVID-19) progression include comorbidity, age, and time from illness onset to antiviral treatment, according to a study published online March 27 in the Journal of Internal Medicine.
Extracorporeal Membrane Oxygenation Might Aid in Severe COVID-19
MONDAY, April 6, 2020 (HealthDay News) — Extracorporeal membrane oxygenation (ECMO) support might improve clinical outcomes in severe cases of coronavirus disease 2019 (COVID-19) that cannot be adequately managed with mechanical ventilation alone, according to research published online March 30 in the ASAIO Journal.
Hydroxychloroquine Can Shorten Time to Recovery in COVID-19
MONDAY, April 6, 2020 (HealthDay News) — Hydroxychloroquine (HCQ) can shorten time to clinical recovery and promote pneumonia absorption among patients with coronavirus disease 2019 (COVID-19), according to a study that has not yet been peer reviewed and was posted online March 31 at medRxiv.org.
Physician’s Briefing Weekly Coronavirus Roundup
Here is what the editors at Physician’s Briefing chose as the most important COVID-19 developments for you and your practice for the week of March 30 to April 3, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.
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Enrollment Begins in NIH-Sponsored Trial of Remdesivir for COVID-19 Patients
FRIDAY, April 3, 2020 (HealthDay News) — A number of institutions this week announced their participation in an international clinical drug trial evaluating the safety and efficacy of remdesivir in hospitalized patients with the novel coronavirus 2019 (COVID-19).
More Information – Northwestern
More Information – Cedars Sinai
More Information – UC Davis
More Information – Roswell Park
More Information – University of Illinois at Chicago
Test Vaccine Elicits Strong Ab Response to SARS-CoV-2 in Mice
FRIDAY, April 3, 2020 (HealthDay News) — Microneedle array (MNA) delivery of trimeric coronavirus spike (S) protein subunit vaccines seems promising for immunization against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, according to research published online April 2 in EBioMedicine.
Presymptomatic Transmission of SARS-CoV-2 ID’d in Singapore
FRIDAY, April 3, 2020 (HealthDay News) — Presymptomatic transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been observed in epidemiological clusters in Singapore, with transmission occurring one to three days before symptom onset, according to research published in the April 1 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.
Model Projects COVID-19 Deaths in Italy Through Mid-April
FRIDAY, April 3, 2020 (HealthDay News) — Modeling suggests that in Italy, the number of coronavirus disease 2019 (COVID-19) intensive care unit (ICU) patients will continue increasing into April, according to a report published April 1 by the European Society of Anaesthesiology.
Amid COVID-19 Crisis, Blood Donor Restrictions Eased
FRIDAY, April 3, 2020 (HealthDay News) — America is in urgent need of blood donations during the COVID-19 pandemic, so the U.S. Food and Drug Administration said Thursday it will relax donor restrictions placed on gay and bisexual men and others.
Gastrointestinal Symptoms Common in COVID-19 Patients
FRIDAY, April 3, 2020 (HealthDay News) — Gastrointestinal symptoms are common in patients with coronavirus disease 2019 (COVID-19), with increased prevalence seen in the later stages of the epidemic in China, according to a review published online March 29 in Alimentary Pharmacology & Therapeutics.
N.Y. Hospital Converts Sleep Apnea Machines Into Ventilators
FRIDAY, April 3, 2020 (HealthDay News) — As COVID-19 pushes American hospitals to the breaking point, intensive care units are finding creative ways to deal with a looming shortage of lifesaving mechanical ventilators.
Northwell Health Press Release
More Information: CDC
Unemployed Workers Less Likely to Be Uninsured Post-ACA
THURSDAY, April 2, 2020 (HealthDay News) — Following implementation of the Affordable Care Act (ACA), unemployed workers were less likely to be uninsured, and uninsurance rates decreased more in states with Medicaid expansion, according to a report from the Urban Institute and the Robert Wood Johnson Foundation.
CT Scores Higher With Longer Time to COVID-19 Diagnosis
THURSDAY, April 2, 2020 (HealthDay News) — Patients with coronavirus disease 2019 (COVID-19) with longer time from symptom onset to diagnosis have higher computed tomography (CT) scores and longer time to disease resolution, according to a study published online March 30 in the American Journal of Roentgenology.
Transmission Control Measures Tied to Delay in COVID-19 Growth
THURSDAY, April 2, 2020 (HealthDay News) — Transmission control measures implemented in Wuhan were associated with a delay in epidemic growth during the first 50 days of the coronavirus disease 2019 (COVID-19) epidemic in China, according to a study published online March 31 in Science.
Burden of Clostridioides difficile Infection Down in the U.S.
THURSDAY, April 2, 2020 (HealthDay News) — From 2011 to 2017, there was a decrease in the estimated national burden of Clostridium difficile infection, according to a study published in the April 2 issue of the New England Journal of Medicine.
Severe COVID-19 Risk Up With Existing Health Conditions in U.S.
WEDNESDAY, April 1, 2020 (HealthDay News) — In the United States, individuals with underlying health conditions have an increased risk for severe coronavirus disease 2019 (COVID-19), according to research published in the March 31 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.
Imported Masks, Other Medical Supplies Arriving in U.S.
WEDNESDAY, April 1, 2020 (HealthDay News) — For the first time since February, imported N95 medical masks are arriving in the United States, but they are not nearly enough to meet demand as COVID-19 cases climb.
Persistent Positive SARS-CoV-2 Found in Sputum, Feces Samples
WEDNESDAY, April 1, 2020 (HealthDay News) — Some patients with coronavirus disease 2019 (COVID-19) remain positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in sputum or feces after pharyngeal samples become negative, according to a research letter published online March 30 in the Annals of Internal Medicine.
U.S. Coronavirus Death Toll Could Reach 240,000, Task Force Warns
WEDNESDAY, April 1, 2020 (HealthDay News) — The White House coronavirus task force delivered a tough statistic to Americans late Tuesday, warning that the U.S. death toll from COVID-19 could climb to 240,000, even with social distancing policies in place.
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