Smaller baseline angle opening distance at 750 µm, larger lens vault linked to development of closure
FRIDAY, Feb. 10, 2017 (HealthDay News) — Baseline anterior segment parameters are associated with development of incident gonioscopic angle closure after four years, according to a study published online Feb. 9 in JAMA Ophthalmology.
Monisha E. Nongpiur, M.D., Ph.D., from the Singapore Eye Research Institute, and colleagues recruited 342 participants aged 50 years or older to a prospective observational study. At baseline and after four years, participants underwent gonioscopy and anterior segment optical coherence tomography imaging.
The researchers found that 14.3 percent of participants developed gonioscopic angle closure after four years. These participants had a smaller baseline angle opening distance at 750 µm (AOD750), trabecular iris surface area at 750 µm, anterior chamber area, and anterior chamber volume (all P < 0.001). These participants also had larger baseline iris curvature and lens vault (LV) measurements (all P < 0.001). Thirty-eight percent of the variance in gonioscopic angle closure occurring at four years was explained by a model consisting of the LV and AOD750 measurements; LV accounted for 28 percent of this variance. The odds of developing gonioscopic angle closure were 1.29 and 3.27, respectively, for every 0.1 mm increase in LV and 0.1 mm decrease in AOD750.
“These findings suggest that smaller AOD750 and larger LV measurements are associated with the development of incident gonioscopic angle closure after four years among participants with gonioscopically open angles at baseline,” the authors write.
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