Increased risk particularly seen with keratinocyte cancer and lymphomas
FRIDAY, March 13, 2020 (HealthDay News) — Patients with psoriasis may have a slightly increased risk for cancer, according to a review published online Feb. 19 in JAMA Dermatology.
Sofie Vaengebjerg, M.D., from University of Copenhagen in Denmark, and colleagues evaluated the association between cancer risk and psoriasis or psoriatic arthritis.
Based on 112 included studies (total 2,053,932 patients), the researchers found that the overall prevalence of cancer in patients with psoriasis was 4.78 percent (95 percent confidence interval [CI], 4.02 to 5.59 percent), with an incidence rate of 11.75 per 1,000 person-years (95 percent CI, 8.66 to 15.31) and a risk ratio (RR) of 1.21 (95 percent CI, 1.11 to 1.33). Increased risk was seen for several cancers, including keratinocyte cancer (RR, 2.28; 95 percent CI, 1.73 to 3.01), lymphomas (RR, 1.56; 95 percent CI, 1.37 to 1.78), lung cancer (RR, 1.26; 95 percent CI, 1.13 to 1.40), and bladder cancer (RR, 1.12; 95 percent CI, 1.04 to 1.19). For patients with psoriasis treated with biologic agents, there was no increased risk for cancer (RR, 0.97; 95 percent CI, 0.85 to 1.10). There was no association between psoriatic arthritis and increased risk for cancer overall (RR, 1.02; 95 percent CI, 0.97 to 1.08).
“Clinicians treating patients with psoriasis should be aware of this increased risk, especially for lymphomas, as immunogenic treatment might be associated with exacerbations,” the authors write.
Several authors disclosed ties to the pharmaceutical industry.
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