No change in overall prevalence from 1988 to 2014; decrease in albuminuria, increase in reduced eGFR
WEDNESDAY, Aug. 10, 2016 (HealthDay News) — From 1988 to 2014 there was no change in the overall prevalence of diabetic kidney disease, according to a study published in the Aug. 9 issue of the Journal of the American Medical Association.
Maryam Afkarian, M.D., Ph.D., from the University of Washington in Seattle, and colleagues characterized the clinical manifestations of kidney disease among U.S. adults with diabetes. Data were obtained from 6,251 adults aged 20 years and older with diabetes mellitus participating in the National Health and Nutrition Examination Surveys from 1988 through 2014.
The researchers observed no change over time in the prevalence of any diabetic kidney disease, defined as persistent albuminuria, persistent reduced estimated glomerular filtration rate (eGFR), or both (prevalence ratio, 0.95; 95 percent confidence interval [CI], 0.86 to 1.06, after adjustment for age, sex, and race/ethnicity). There was a decrease in the prevalence of albuminuria over time (adjusted prevalence ratio, 0.76; 95 percent CI, 0.65 to 0.89). The prevalence of reduced eGFR increased over time (adjusted prevalence ratio, 1.61; 95 percent CI, 1.33 to 1.95), and a similar pattern was seen for severely reduced eGFR (adjusted prevalence ratio, 2.86; 95 percent CI, 1.38 to 5.91).
“Among U.S. adults with diabetes from 1988 to 2014, the overall prevalence of diabetic kidney disease did not change significantly, whereas the prevalence of albuminuria declined and the prevalence of reduced eGFR increased,” the authors write.
Several authors disclosed financial ties to the pharmaceutical and medical technology industries.
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