Significantly lower median µOCT for oncocytoma versus renal cell carcinoma
FRIDAY, April 29, 2016 (HealthDay News) — Percutaneous needle-based optical coherence tomography (OCT) can differentiate renal masses, according to a study published in the May issue of The Journal of Urology.
Peter G.K. Wagstaff, from AMC University Hospital in the Netherlands, and colleagues performed percutaneous needle-based OCT of the kidney in patients presenting with a solid renal mass. They obtained pathology specimens as biopsies and/or resection specimens. In order to derive the attenuation coefficient (µOCT) values of oncocytoma and renal cell carcinoma, they correlated optical coherence tomography results of 40 patients to pathology results of the resected specimens.
The researchers found that the median µOCT was significantly lower for oncocytoma versus renal cell carcinoma. In receiver operating curve (ROC) analysis, a µOCT cutoff value of 3.8 mm−1 could differentiate between oncocytoma and renal cell carcinoma with sensitivity, specificity, positive predictive value, and negative predictive value of 86, 75, 97, and 37 percent, respectively; 0.81 was the area under the ROC. The median µOCT was significantly lower for oncocytoma versus clear cell renal cell carcinoma and papillary renal cell carcinoma (P = 0.049 and 0.027, respectively).
“We demonstrated that the µOCT is significantly higher in renal cell carcinoma versus oncocytoma, with ROC analysis showing promising results for their differentiation,” the authors write.
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