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Monthly Archives: January 2018

A novel oral dosage form enables sustained release of antiretrovirals

Week’s Worth of HIV Meds in a Single-Dose Capsule Feasible

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Oral platform delivers three antiretrovirals for up to seven days after single administration
The use of idalopirdine does not improve cognition versus placebo over 24 weeks of treatment for patients with mild-to-moderate Alzheimer's disease

Idalopirdine May Not Improve Cognition in Mild Alzheimer’s

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Findings from three randomized trials show no improvement in cognition vs. placebo over 24 weeks
The U.S. Preventive Services Task Force has concluded that the current evidence is insufficient to assess the balance of benefits and harms of screening for adolescent idiopathic scoliosis in children and adolescents aged 10 to 18 years. The recommendation statement has been published in the Jan. 9 issue of the Journal of the American Medical Association.

USPSTF Questions Adolescent Idiopathic Scoliosis Screening

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Finds insufficient evidence on balance of benefits and harms of screening asymptomatic 10- to 18-year-olds
The contributions of screening and treatment to decreases in breast cancer mortality vary by molecular subtype

Screening, Therapy Effect Varies by Breast CA Molecular Subtype

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Reductions in breast cancer mortality linked to screening and treatment, but associations vary
Job satisfaction and practice environment are associated with moral distress among critical care nurses

ICU RN Job Dissatisfaction, Burnout Linked to Moral Distress

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Age and negative perception of job satisfaction, practice environment all predictors of moral distress
There is urban and rural variation in fertility-related behavior among U.S. women

Urban, Rural Variation in Fertility-Related Behaviors for U.S. Women

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Younger average age at first intercourse in rural areas; more women in rural areas had ≥1 birth
There is a positive association between long-term night shift work and the risk of several common cancers for women

Long-Term Night Shift Work Linked to Cancer Risk in Women

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Dose-response pattern seen, with increased risk of breast cancer for every five years of night shift work
There have been recent modest declines in severe obesity among young children

Recent Modest Declines Noted in Severe Obesity in Children

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In children aged 2 to 4, prevalence rose from 2000 to 2004, then fell from 2004 to 2010 and 2010 to 2014
Rituximab has better efficacy and lower discontinuation rates than other disease-modifying treatment choices for newly diagnosed relapsing-remitting multiple sclerosis

Rituximab Tops Other Disease-Modifying Tx Options in MS

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Better efficacy, lower discontinuation rate in newly diagnosed relapsing-remitting multiple sclerosis
Assessing change in the CHA2DS2-VASc score over time is more predictive of ischemic stroke in patients with atrial fibrillation than the baseline score

Follow-Up Delta CHA2DS2-VASc Score Better Predicts CVA in A-Fib

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CHA2DS2-VASc score not static; most a-fib patients develop new risk factor before ischemic stroke